Importance of Early High Dose Vitamin B in Diabetic Neuropathy

High dose combination of vitamin B such as B1, B6 and B12 plays an important role in preventing or slowing down the progression of diabetic neuropathy.

Vitamin B1 – Thiamine

Peripheral neuropathy is associated with impairment of thiamine metabolism. Thiamine, which is necessary for carbohydrate metabolism, is rapidly depleted in diabetics due to high demand by cells needing to manage the high glucose levels. Thiamine or Vitamin B1 deficiency mainly leads to nerve damage. This may cause extreme pain and may affect numerous processes in your body; including proper function of the muscular and neurological systems. In addition, Thiamine deficiency can manifest as a problem with your metabolism which can lead to impairment of your digestive system and decrease your processing of glucose. This can cause you to develop high blood sugar levels that are typical of uncontrolled diabetes and leading to to neuropathy. Researchers found that diabetics are thiamine deficient due to a failure in retaining the B vitamin in the body. As the body cannot produce thiamine, a continuous supply of high dose thiamine can be achieved by thiamine supplements.

Vitamin B6 – Pyridoxine

Deficiency of vitamin B6 or Pyridoxine, is common if you already have diabetic neuropathy. Vitamin B6 is a water soluble vitamin that aids the glucose transport system in the body. Without enough of this vitamin, your glucose remains high as your body struggles to process it into energy. Excess glucose levels can cause damage to your neurological system, leading to diabetic neuropathy. Vitamin B6 is necessary for proper conduction of nerve impulses. Vitamin B6 deficiency may be another cause of peripheral neuropathy in diabetics.

Vitamin B12 – Cobalamin

Vitamin B12 is extremely important to overall nerve health. Diabetics are often deficient in this vitamin, which causes the classic numbness and tingling of peripheral neuropathy in the feet and hands. When vitamin B12 deficiency occurs chronically, the protective layer (myelin sheath) that surrounds and protects your nerves becomes prone to damage, which then manifests itself as neuropathy. Deficiencies of vitamin B12 are typically treated with high dose of vitamin B12. Vitamin B12, a water soluble vitamin, is also necessary for red blood cell formation and DNA synthesis. Animal based foods such as meat products are good sources of vitamin B12; however, you may not be able to absorb enough to prevent a deficiency due to certain conditions. Thus, you may require vitamin B12 supplements from your healthcare professionals.

 

Reference:

  1. National Institute of Diabetes and Digestives and Kidney Diseases. Diabetic Neuropathies: The Nerve Damage of Diabetes. February 2009, pp. 1-12.
  2. Tong, H I. Influence of Neurotropic Vitamins on the Nerve Conduction Velocity in Diabetic Neuropathy. Annals Academy of Medicines. January 1980, Vol. 9, 1.
  3. Louis V. Gerstner, Jr. Graduate School of Biomedical Sciences. Cancer Information. Memorial Sloan-Kettering Cancer Centre. [Online] Sloan-Kettering Institute, 2011. [Cited: September 7, 2011.] http://www.mskcc.org/mskcc/html/69411.cfm.
  4. V., Bor, et al., et al. Plasma Vitamin B6 Vitamers Before and After Oral Vitamin B6 Treatment: A Randomized Placebo-controlled Study. Clinical Chemistry. 2003, Vol. 49, 1, pp. 155–161.
  5. N, Rabanni, et al., et al. High-dose Thiamine Therapy for Patients with Type 2. Diabetologia. 2009, Vol. 52, pp. 208–212.
  6. Center for Peripheral Neuropathy. Types of Peripheral Neuropathy – Systemic / Metabolic. Learn About Peripheral Neuropathy. [Online] 4 16, 2010. [Cited: 4 26, 2011.] http://peripheralneuropathycenter.uchicago.edu/ learnaboutpn/typesofpn/systemic/nutrition.shtml.
  7. Mayo Clinic. Thiamine (Vitamin B1). Mayo Clinic. [Online] Mayo Foundation for Medical Education and Research, 2011. [Cited: 10 14, 2011.] http://www.mayoclinic.com/health/vitamin-b1/NS_patient-thiamin.

 

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